Single-celled organisms

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A note for The Half-Lesson, "Your Brain Is Not for Thinking," in Seven and a Half Lessons About the Brain by Lisa Feldman Barrett.
Some context from page 8‌ is:

Prediction is such a useful capability that even single-celled creatures plan their actions predictively.

Single-celled organisms somehow predict without a nervous system.[1][2]


  1. Freddolino, Peter L. and Saeed Tavazoie. 2012. “Beyond Homeostasis: A Predictive-Dynamic Framework for Understanding Cellular Behavior.” Annual Review of Cell Developmental Biology 28: 363–84.
  2. Lyon, Pamela. 2015. “The Cognitive Cell: Bacterial Behavior Reconsidered.” Frontiers in Microbiology 6: 264.